Recent advances in immune therapy for patients with non-small cell lung cancer (NSCLC) have taken a long-awaited step forward and shifted the standard of care of patients with advanced and metastatic disease. Understanding the mechanisms of new and emerging therapies and the critical need for genomic testing are vital to implementing successful treatment of patients with this of difficult-to-treat type of cancer. Historically, NSCLC tumor cells have successfully evaded standard approaches to treatment including chemotherapy regimens and radiation therapy. Research has advanced our understanding of the tumor microenvironment and opened the door for immunotherapy treatment that engages that body’s natural immune system. Clinical trials of both approved and emerging therapies are associated with impressive responses to treatment, are answering important questions, and are providing new insight into personalizing therapy. New criteria designed to monitor patients’ tumor response to immunotherapies and aid in informing treatment are now part of the treatment paradigm. This case-based module provides education on recently approved immunotherapies and their limitations in patients with NSCLC, discusses clinical trials underway with new and emerging agents, provides insight into monitoring treatment response, and touches on considerations that may affect personalized treatment decisions and combination therapy approaches.
The goal of this activity is to provide participants with knowledge to assist in evaluating the efficacy and safety of immunotherapies, implement genetic screening, and formulate individualized treatment plans for patients with metastatic NSCLC.
This activity is designed for oncology healthcare providers (oncologists, oncology nurses, and oncology physician assistants) who care for patients with NSCLC. No prerequisites required.
After participating in this activity, the participant will demonstrate the ability to:
- EVALUATE the efficacy and safety of immunotherapy as part of NSCLC treatment paradigms.
- FORMULATE individualized treatment plans for NSCLC using patient case scenarios.
The Johns Hopkins University School of Medicine and the Institute for Johns Hopkins Nursing take responsibility for the content, quality, and scientific integrity of this CME/CNE activity.
Full Disclosure Policy Affecting CME Activities
As a provider approved by the Accreditation Council for Continuing Medical Education (ACCME), it is the policy of the Johns Hopkins University School of Medicine Office of Continuing Medical Education (OCME) to require signed disclosure of the existence of financial relationships with industry from any individual in a position to control the content of a CME activity sponsored by OCME. Members of the Planning Committee are required to disclose all relationships regardless of their relevance to the content of the activity. Faculty are required to disclose only those relationships that are relevant to their specific presentation.
Policy on Faculty and Provider Disclosure
It is the policy of the Institute for Johns Hopkins Nursing to require our continuing nursing education faculty and planning committee members to disclose any financial relationships with companies providing program funding or manufacturers of any commercial products discussed in the educational activity.
The following relationships have been reported for this activity:
Chair, Planner, and Faculty
David S. Ettinger, MD
Alex Grass Professor in Oncology
Sidney Kimmel Comprehensive Cancer Center
Rebecca Barshick, RN, MSN
The Institute for Johns Hopkins Nursing
MiKaela Olsen, APRN-CNS, MS, AOCNS
Oncology and Hematology Clinical Nurse Specialist
Sidney Kimmel Comprehensive Cancer Center
Johns Hopkins Hospital and Greenspring Oncology
Dr. Ettinger reports serving as a principal investigator for Golden Biotechnology Corp; serving on the data monitoring committee for ARIAD Pharmaceuticals Inc; and serving as a consultant for Boehringer Ingelheim, Bristol-Myers Squibb Company, Eli Lilly and Company, EMD Serono Inc, Genentech Inc. and Helsinn Therapeutics, Inc.
Grants to investigators at The Johns Hopkins University are negotiated and administered by the institution that receives the grants, typically through the Office of Research Administration. Individual investigators who participate in the sponsored project(s) are not directly compensated by the sponsor, but may receive salary or other support from the institution to support their effort on the project(s).
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(Updated 4/09 and 3/14)
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The mission of the Institute for Johns Hopkins Nursing is to share the innovations of Johns Hopkins Nursing in practice, education, and research—locally, nationally, and globally. Our goal in continuing nursing education is to bring you activities that reflect the expertise and creativity of Johns Hopkins Nursing. Our service values are quality, integrity, flexibility, and personal attentiveness. We appreciate your thoughts and welcome your concerns—please feel free to e-mail us: IJHN@.jhmi.edu
The following is an interactive case module designed to help you gauge your basic knowledge of the topic and then direct you to areas you may need to focus on. It consists of 3 sections: an unaccredited pre-test, an interactive case study, and a CME/CNE post-test and evaluation. All 3 sections must be completed to receive CME/CNE credit. A certificate of participation will be available online immediately following successful completion of the activity.
PreassessmentThis activity was developed in collaboration with ASiM.
Considerations for Using Immune Therapy in Treating Metastatic Non-Small–Cell Lung Cancer
David S. Ettinger, MD
Postassessment and Evaluation