Advances in Soft-Tissue Sarcoma
Presented by the Johns Hopkins University School of Medicine.
Supported by an educational grant from Lilly & Co, Inc.
Soft-tissue sarcomas (STSs) are a heterogeneous collection of rare tumors. As such, they can arise within any site of the body, including the extremities, trunk, retroperitoneum, and head and neck. There are over 50 different histological subtypes, which can make accurate diagnosis challenging. STS accounts for about 58% of all sarcomas with the remainder diagnosed as sarcomas of the bone and viscera. Outcomes for patients with STS are poor, and local recurrence and metastases are common. The development of new treatments for patients with STS has been stymied by its rarity, which has a limited the number of clinical trials, trial participants, and new agents. However, recently, 4 new therapies have been approved for treating patients with high-grade STS. This activity will explore the challenges in the current care of patients with STS and prospects for improved, more personalized therapy approaches in the future.
The goal of this activity is to provide oncology healthcare providers with knowledge that can be applied to developing a treatment plan for their patients with STS.
This activity is intended for oncology healthcare providers who care for patients with STS. No prerequisites required.
After participating in this activity, the participant will demonstrate the ability to:
- IDENTIFY clinical and pathological characteristics of STS and challenges of traditional treatment strategies.
- EVALUATE the efficacy and safety of first-line STS treatments, including recent changes to clinical practice guidelines.
- DESIGN a treatment plan for second-line STS therapy, incorporating newly approved agents utilized in various subtypes of STS.
The Johns Hopkins University School of Medicine takes responsibility for the content, quality, and scientific integrity of this CME activity.
Policy on Speaker and Provider Disclosure
The Johns Hopkins University School of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.
Credit Designation Statement —
The Johns Hopkins University School of Medicine designates this enduring material for a maximum of 1.0 AMA PRA Category 1 CreditTM
. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
After reviewing this online activity, participants may receive a certificate by receiving a score of 70% or higher on the CME test and completing an evaluation. A certificate of participation will be available online immediately following successful completion of the activity.
The estimated time to complete this activity: 60 minutes.
December 15, 2017 Expiration date:
December 15, 2018
It is the policy of the Johns Hopkins University School of Medicine that the speaker and provider globally disclose conflicts of interest. The Johns Hopkins University School of Medicine OCME has established policies in place that will identify and resolve all conflicts of interest prior to this educational activity. Detailed disclosure will be made in the instructional materials.
Full Disclosure Policy Affecting CME Activities
As a provider approved by the Accreditation Council for Continuing Medical Education (ACCME), Johns Hopkins University School of Medicine Office of Continuing Medical Education (OCME) requires attested and signed global disclosure of the existence of all financial interests or relationships with commercial interest from any individual in a position to control the content of a CME activity sponsored by OCME. The following relationships have been reported for this activity:
The following relationships have been reported for this activity:
Dr. Ettinger reports serving as a principal investigator for Golden Biotechnology Corp; serving as a consultant for AbbVie Inc, BeyondSpring Pharmaceuticals, Inc, Boehringer-Ingelheim GmbH, Bristol-Myers Squibb Company, Eli Lilly and Company, EMD Serono Inc, Guardant Health Inc, Genentech Inc, Helsinn Therapeutics Inc, Herron Therapeutics, and sanofi-aventis, US LLC.
Dr Ahuja reports serving as a contracted researcher for Astex Pharmaceuticals and Cepheid; serving as a consultant for Johnson & Johnson; and for licensed biomarkers for Cepheid.
No other planners or faculty have indicated that they have any financial interests or relationships with a commercial entity.
Note: Grants to investigators at The Johns Hopkins University are negotiated and administered by the institution that receives the grants, typically through the Office of Research Administration. Individual investigators who participate in the sponsored project(s) are not directly compensated by the sponsor, but may receive salary or other support from the institution to support their effort on the project(s).
Chair and Planner
David S. Ettinger, MD
Alex Grass Professor of Oncology
Sidney Kimmel Comprehensive Cancer Center
Nita Ahuja, MD
Professor of Surgery, Oncology, and Urology
Johns Hopkins University School of Medicine
Chung-Shien Lee, PharmD, BCPS, BCOP
Assistant Clinical Professor
Department of Clinical Pharmacy Practice
St. John’s University
College of Pharmacy and Health Sciences
Queens, New York
Bradley N. Reames, MD, MS
Complex General Surgical Oncology Fellow
Department of Surgery
Johns Hopkins Hospital
The opinions and recommendations expressed by faculty and other experts whose input is included in this activity are their own. This activity is produced for educational purposes only. Use of Johns Hopkins University School of Medicine name implies review of educational format, design, and approach. Please review the complete prescribing information of specific drugs or combinations of drugs, including indications, contraindications, warnings, and adverse effects before administering pharmacologic therapy to patients.
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The following is an interactive case module designed to help you gauge your basic knowledge of the topic and then direct you to areas you may need to focus on. It consists of 3 sections: an unaccredited pre-test, an interactive case study, and a CME post-test and evaluation. All 3 sections must be completed to receive CME credit. A certificate of participation will be available online immediately following successful completion of the activity.
PreassessmentThis activity was developed in collaboration with ASiM.
Advances in Soft Tissue Sarcoma
Nita Ahuja, MD, Chung-Shien Lee, PharmD, BCPS, BCOP , and Bradley N. Reames, MD, MS
Postassessment and Evaluation